Charlene was admitted to the Maltese Bar and granted her warrant to practice as a lawyer in 2018. She obtained her Bachelor of Laws (Honours) degree in 2016 and her Master of Advocacy in 2017 at the University of Malta. She joined Mifsud & Mifsud Advocates as a legal trainee in 2015, assisting with legal research and drafting. Charlene specialises in Employment and Shipping law, assisting clients in litigation matters, negotiating settlements, drafting and vetting of contracts, shipping registrations, and other general corporate duties.

Charlene previously worked at Aegis Corporate Services Limited and was responsible of incorporating a number of companies for local and international clients. She has also served as the President of the Junior Chamber of Advocates from 2016 to 2017 and formed part of the organising committee of the international conference, MaltMUN.